OPTIMIZATION APPROACHES TO PREVENTION TB IN PENITENTIARY INSTITUTIONS


Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface

Abstract Background This study aimed to delineate the cell heterogeneity in the bone-implant interface and investigate the fibroblast responses to implant-associated S.aureus infection.Methods Single-cell RNA sequencing of human periprosthetic tissues from patients with periprosthetic joint infection (PJI, n = 3) and patients with aseptic loosening

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The influence of microbial colonization on inflammatory versus pro-healing trajectories in combat extremity wounds

Abstract A combination of improved body armor, medical transportation, and treatment has led to the increased survival of warfighters from combat extremity injuries predominantly caused by blasts in modern conflicts.Despite advances, a high rate of complications such as wound infections, wound failure, amputations, and a decreased quality of life e

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